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A COMPARATIVE STUDY OF THE ACTION OF FRUSEMIDE AND METHYCLOTHIAZIDE ON RENIN RELEASE BY RAT KIDNEY SLICES AND THE INTERACTION WITH INDOMETHACIN
Author(s) -
DESAULLES E.,
SCHWARTZ J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07818.x
Subject(s) - macula densa , furosemide , diuretic , renin–angiotensin system , chemistry , endocrinology , thiazide , medicine , kidney , hydrochlorothiazide , in vivo , tubuloglomerular feedback , juxtaglomerular apparatus , pharmacology , biology , microbiology and biotechnology , blood pressure
1 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. 2 Frusemide at concentrations of 1.5 and 7.5 mmol/1 produced significant increases in renin release but had no effect at 0.15 mmol/1. 3 Methyclothiazide in a similar concentration range did not increase renin release; instead, at the highest concentration used, methyclothiazide (3.5 mmol/1) inhibited renin release. 4 Indomethacin (25 μmol/1) did not inhibit the increase of renin induced by frusemide. 5 Our limited study in vitro is consistent with the findings of other workers who have shown in vivo , in the absence of systemic electrolyte depletion, that only loop diuretics' increase renin secretion. Under our experimental conditions, it is suggested that frusemide exerts a direct action either upon the epithelioid cells or upon the macula densa since the renal prostaglandin system does not intervene.