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CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE AND THE MECHANISM OF ACTION OF THREE COMMON ANTI‐INFLAMMATORY DRUGS
Author(s) -
DEPORTER D.A.,
DUNN C.J.,
WILLOUGHBY D.A.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07814.x
Subject(s) - colchicine , adenosine , cyclic adenosine monophosphate , theophylline , mechanism of action , pharmacology , chemistry , cyclic gmp , dexamethasone , adenosine monophosphate , medicine , cyclic nucleotide , endocrinology , enzyme , nucleotide , biochemistry , receptor , in vitro , gene
1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3′, 5′‐monophosphate (cyclic AMP) concentration in leucocytes during a crystal‐induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels were returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti‐inflammatory drug.