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RELEASE OF [ 3 H]‐N0RADRENALINE FROM THE MOTOR ADRENERGIC NERVES OF THE ANOCOCCYGEUS MUSCLE BY LYSERGIC ACID DIETHYLAMIDE, TYRAMINE OR NERVE STIMULATION
Author(s) -
McGRATH J.C.,
OLVERMAN H.J.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17324.x
Subject(s) - tyramine , carbachol , chemistry , stimulation , endocrinology , adrenergic , medicine , free nerve ending , lysergic acid diethylamide , nerve stimulation , pharmacology , biochemistry , receptor , biology , serotonin
1 A method is described for labelling the neuronal noradrenaline (NA) stores of rat anococcygeus with [ 3 H]‐NA and detecting subsequent release of 3 H from the superfused tissue by nerve stimulation or drugs. 2 Lysergic acid diethylamide (LSD) or tyramine but not barium chloride or carbachol increased the efflux of 3 H although each drug produced an equivalent contractile response. This confirms that LSD has an indirect sympathomimetic action. 3 LSD was found to produce a proportionately smaller reduction of the nerve‐induced efflux of 3 H than of the accompanying contractile response. 4 The inhibition of nerve‐induced contractile responses by LSD was shown to be independent of the neuronal uptake of noradrenaline and any post‐junctional inhibition demonstrated to be non‐specific.