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THE EFFECTS OF PENTOBARBITONE AND URETHANE ON PULMONARY AIRWAY RESISTANCE IN GUINEA‐PIGS AND THEIR INTERACTIONS WITH DRUGS
Author(s) -
ADVENIER C.,
BOISSIER J.R.,
HO S.,
MALLARD B.,
RUFF F.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17313.x
Subject(s) - atropine , bronchodilator , propranolol , acetylcholine , histamine , adrenergic , bronchoconstriction , cholinergic , reflex , guinea pig , pharmacology , airway resistance , anesthesia , bronchodilator agents , chemistry , medicine , endocrinology , airway , asthma , receptor
1 Propranolol increased pulmonary airway resistance (PAR) in the conscious guinea‐pig, whereas atropine had no effect, suggesting the existence of a continual sympathetic bronchodilator tone. 2 The direct bronchoconstrictor effects of histamine, acetylcholine and 5‐hydroxytryptamine were modified by autonomic reflexes: a bronchodilator one, abolished by propranolol, and a cholinergic bronchoconstrictor one, seen with histamine. 3 Pentobarbitone increased PAR, an effect which was reduced by propranolol but which was unaffected by atropine. The bronchoconstrictor effects of histamine, acetylcholine and 5‐hydroxytryptamine were potentiated by pentobarbitone. 4 Pentobarbitone therefore appears to inhibit the adrenergic bronchodilator tone and to depress adrenergic reflexes, these being the preponderant autonomic influences in these experiments. 5 Like pentobarbitone, urethane increased PAR in the conscious guinea‐pig and potentiated the bronchoconstrictor effects of the three amines. These actions are similarly attributed to a reduction in adrenergic influences.