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EFFECTS OF SULPHINPYRAZONE AND ASPIRIN ON PROSTAGLANDIN I 2 (PROSTACYCLIN) SYNTHESIS BY ENDOTHELIAL CELLS
Author(s) -
GORDON J.L,
PEARSON J.D.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17308.x
Subject(s) - prostacyclin , aspirin , sulfinpyrazone , endothelium , platelet , prostaglandin , chemistry , pharmacology , drug , medicine , biochemistry , endocrinology
Synthesis of prostaglandin I 2 , (PGI 2 , prostacyclin) by vascular endothelium (assayed by the ability of cultured endothelial cells to inhibit platelet aggregation) was inhibited by aspirin. At 100 μmol/1 aspirin completely blocked measurable PGI 2 production, but endothelial cells had substantially recovered their ability to synthesize PGI 2 24 h after removal of the drug. In contrast, the effect of 1 mmol/1 aspirin was still evident 24 h after drug withdrawal. Sulphinpyrazone also inhibited PGI 2 synthesis, but was about 100 fold less potent than aspirin, and the effect of the drug was lost within 24 h of its addition, even when endothelial cells were left in contact with the drug during this period.