Premium
CHANGES IN PLASMA NORADRENALINE CONCENTRATION AS A MEASURE OF RELEASE RATE
Author(s) -
BENEDICT C.R.,
FILLENZ M.,
STANFORD CLARE
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17305.x
Subject(s) - chemistry , adrenalectomy , plasma concentration , endocrinology , plasma , medicine , biophysics , biology , physics , quantum mechanics
1 A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy. 2 Exogenous NA has a half‐life of 1.5 min; drugs which block neuronal and extra‐neuronal uptake lengthen this to 6.3 min. 3 Swim‐stress leads to a steep rise followed by a rapid decline in plasma NA concentration. 4 This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.