Premium
INHIBITION BY N‐ACETYL NEURAMINIC ACID OF PLATELET THROMBOGENESIS INDUCED BY LASER INJURY TO RAT AND HAMSTER VENULES
Author(s) -
BORN GUSTAV V.R.,
KOVACS IREN B.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17304.x
Subject(s) - cheek pouch , neuraminic acid , platelet , hamster , chemistry , barbiturate , medicine , endocrinology , pharmacology , biochemistry , sialic acid
1 In rats and hamsters under barbiturate anaesthesia, laser radiation to venules about 50 μm in diameter in mesoappendix and cheek pouch respectively caused the formation of platelet thrombi which occluded the vessels in about 9 min. 2 This occlusion time was significantly prolonged by the intravenous injection of N‐acetyl neuraminic acid (NANA) but not by D‐glucuronic acid or β‐methoxyneuraminic acid, in doses which had no effect on blood pH or on the condition of the animals. 3 The results confirm the antithrombotic effect of NANA previously demonstrated with another technique.