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ADRENOCORTICOTROPHIC HORMONE FRAGMENTS MIMIC THE EFFECT OF MORPHINE in vitro
Author(s) -
PLOMP GERDA J.J.,
REE JAN M.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17293.x
Subject(s) - morphine , adrenocorticotrophic hormone , chemistry , endocrinology , (+) naloxone , endorphins , medicine , receptor , antiserum , in vitro , adrenocorticotropic hormone , opioid , hormone , biochemistry , antibody , immunology
1 Fragments of the N terminal part of adrenocorticotrophic hormone (ACTH) inhibited the electrically evoked contractions of the mouse vas deferens. This inhibition could be antagonized by naloxone. 2 The same fragments displaced radiolabelled morphine from morphine antiserum. 3 Structure‐activity relationship studies showed that in both assay systems the active core is located within the sequence ACTH 7–10. 4 It is postulated that the Trp 9 residue and the peptide bond between Trp 9 and Gly 10 are particularly important for interaction of ACTH fragments with morphine receptors.