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E. col/ ENDOTOXIN SHOCK IN THE DOG; TREATMENT WITH LIDOCAINE OR INDOMETHACIN
Author(s) -
FLETCHER J.R.,
RAMWELL P.W.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17288.x
Subject(s) - lidocaine , prostaglandin , medicine , shock (circulatory) , anesthesia , blood pressure , fibrinogen , pharmacology , local anesthetic
1 Dogs treated with lidocaine (1 mg kg −1 h −1 ) or indomethacin (1.5 mg/kg) before and after an LD 60 dose (1 mg/kg) of E. coli endotoxin survived for at least 72 h. 2 Although all dogs in both treated groups survived, only those treated with indomethacin were significantly protected against the fall in the arterial blood pressure 1 to 2 min following endotoxin administration. 3 Endotoxin increased the plasma prostaglandin F 2α (PGF 2α ) concentration in the control and lidocaine‐treated groups, however, no increase was observed with indomethacin treatment. 4 Neither lidocaine nor indomethacin alone had any significant effect on the parameters measured in this model. 5 Following the administration of endotoxin, lidocaine‐treated animals had significantly decreased plasma fibrinogen concentrations when compared to the other groups. 6 This study suggests that lidocaine, a local anaesthetic and a drug widely used for cardiac arrhythmias, might offer protection in endotoxin shock.