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COMPARISON OF THE ELECTROCORTICAL CHANGES INDUCED BY (+)‐AMPHETAMINE AND CHLORPROMAZINE WHEN PERFUSED DIRECTLY INTO THE DORSAL RAPHE NUCLEUS OF THE CAT
Author(s) -
KEY B.J.,
KRZYWOSINSKI L.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb17272.x
Subject(s) - amphetamine , dorsal raphe nucleus , guanethidine , chemistry , median raphe nucleus , chlorpromazine , dextroamphetamine , serotonin , propranolol , nucleus , endocrinology , medicine , pharmacology , anesthesia , neuroscience , stimulation , biology , serotonergic , dopamine , receptor
1 (+)‐Amphetamine mimicked the intermittent and sustained electrocortical desynchronization produced by (—)‐noradrenaline (NA) when perfused directly into the dorsal raphe nucleus of cat ence‐phale isole preparations. 2 The effects of amphetamine or NA were abolished or significantly attenuated by prior application of (—)‐propranolol. 3 The effect of amphetamine, but not that of NA, was blocked by prior applications of guanethidine or chlorpromazine (CPZ). 4 Desmethylimipramine (DMI) produced dose‐related changes in electrocortical activity which were similar to those induced by NA when applied to the same sites within the dorsal raphe nucleus. 5 DMI potentiated the effects of both amphetamine and NA, but guanethidine only abolished the DMI‐induced potentiation of the amphetamine response. 6 (—)‐Propranolol, guanethidine and CPZ produced a short period of electrocortical desynchronization at the beginning of the perfusion period before antagonism of the amphetamine response was apparent. 7 The results suggest that CPZ and amphetamine have an action within the dorsal raphe nucleus possibly related to noradrenergic terminals.