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THE ROLE OF β 1 ‐ AND β 2 ‐ADRENOCEPTORS IN THE INHIBITION OF GASTRIC ACID SECRETION IN THE DOG
Author(s) -
DALY M.J.,
LONG JANET M.,
STABLES R.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08652.x
Subject(s) - practolol , propranolol , isoprenaline , salbutamol , endocrinology , medicine , pentagastrin , gastric acid , chemistry , secretion , pharmacology , stimulation , asthma
1 Characterization of the β‐adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)‐propranolol, practolol and H 35/25 on salbutamol and isoprenaline‐induced inhibition of gastric acid secretion. 2 The gastric antisecretory effect of salbutamol was significantly blocked by propranolol and H35/25 but not by practolol or (+)‐propranolol. The effect of isoprenaline was significantly blocked by propranolol and practolol but not by H35/25 or (+)‐propranolol. 3 It is concluded that both β 1 ‐ and β 2 ‐adrenoceptors can mediate inhibition of pentagastrin‐induced gastric secretion in conscious dogs with a Heidenhain pouch. Salbutamol exerts its antisecretory effect through β 2 ‐adrenoceptors, whereas isoprenaline mediates its effects primarily through β 1 ‐adrenoceptors. 4 The results are discussed with regard to the sub‐classification of β‐adrenoceptors and to the possible role of adrenoceptors in the physiological control of gastric secretion. 5 In this study it is concluded that the tachycardia induced by isoprenaline or salbutamol is mediated primarily through reflexes activated by β 2 ‐adrenoceptor mediated vasodilatation.