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ANTI‐DEPRESSANT ACTION OF CAESIUM CHLORIDE AND ITS MODIFICATION OF CHLORPROMAZINE TOXICITY IN MICE
Author(s) -
MESSIHA F.S.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08634.x
Subject(s) - depressant , chlorpromazine , toxicity , pharmacology , action (physics) , chemistry , toxicology , medicine , biology , organic chemistry , physics , quantum mechanics
1 Adult male mice were treated with caesium chloride (1.0 mEq/kg, i.p.) once daily for 54 consecutive days before administration of a single dose of reserpine (2.0 mg/kg) or (+)‐amphetamine (1.0 mg/kg). Pretreatment with caesium chloride resulted in potentiation of amphetamine‐produced enhancement of motility and in antagonism of reserpine‐induced behavioural depression in mice as measured by a locomotor activity test, compared to the respective controls. 2 Chronic administration of caesium chloride (1.0 mEq/kg daily) with gradual dose build‐up of chlorpromazine (up to 50 mg kg −1 day −1 ) counteracted chlorpromazine‐produced mortality in mice. 3 The results suggest an antidepressant property for Cs + and the combined treatment of caesium chloride with chlorpromazine might have a clinical application, i.e. in the management of chlorpromazine‐induced adverse reactions.