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SULPHASALAZINE IS A POTENT INHIBITOR OF PROSTAGLANDIN 15‐HYDROXYDEHYDROGENASE: POSSIBLE BASIS FOR THERAPEUTIC ACTION IN ULCERATIVE COLITIS
Author(s) -
HOULT J.R.S.,
MOORE P.K.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08633.x
Subject(s) - ulcerative colitis , prostaglandin , arachidonic acid , pharmacology , chemistry , mechanism of action , in vitro , prostaglandin e2 , medicine , colitis , enzyme , biochemistry , immunology , disease
Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15‐hydroxydehydrogenase in rabbit colon (ID 5() = 50 μ m ) and in several other organs of different species, but does not inhibit prostaglandin A‐13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.