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EFFECTS OF A NEW SELECTIVE β 1 ‐ADRENOCEPTOR AGONIST ON AMYLASE SECRETION FROM THE RAT PAROTID GLAND
Author(s) -
CARLSÖÖ BENGT,
DANIELSSON AKE,
HENRIKSSON ROGER
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08470.x
Subject(s) - endocrinology , medicine , secretion , agonist , secretagogue , parotid gland , terbutaline , amylase , stimulation , chemistry , receptor , isoprenaline , enzyme , adrenergic receptor , biology , biochemistry , dentistry , asthma
The effects of a new selective β 1 ‐adrenoceptor agonist, (−)‐1‐(4‐hydroxyphenoxy)‐3‐isopropyl‐amino‐pro‐panol‐2‐hydrochloride (H 133/22), on amylase secretion from the rat parotid gland were investigated in an in vitro system. The results were compared to the secretory responses obtained with noradrenaline, adrenaline, methoxyamine and terbutaline. H 133/22 was found to be a potent enzyme secretagogue and appeared even more effective than noradrenaline and adrenaline, particularly at low concentrations. The β 2 ‐adrenoceptor agonist, terbutaline, also stimulated amylase discharge from the parotid gland but was much less potent than H 133/22. Methoxyamine had no effect on enzyme secretion. We suggest that the adrenergic stimulation of amylase secretion from the rat parotid gland is mainly mediated by β 1 ‐receptors.