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DIMINISHING HYPOTENSIVE EFFECT OF INCREASING DOSES OF PINDOLOL IN DOCA/SALINE HYPERTENSIVE RATS
Author(s) -
BUCKINGHAM R.E.,
HAMILTON T.C.,
ROBSON D.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08469.x
Subject(s) - pindolol , saline , medicine , endocrinology , anesthesia , propranolol
In DOCA‐saline hypertensive rats, pindolol (4, 20 or 50 mg/kg orally) produced a hypotensive effect which was inversely related to dose. Following adrenal demedullation, a hypotensive response to the highest dose of pindolol was unmasked and the magnitude of the responses to lower doses was increased. The results suggest that adrenal catecholamines moderate the hypotensive effects of high doses of pindolol.