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H 1 ‐ AND H 2 ‐RECEPTORS IN THE SMOOTH MUSCLE OF THE RUMINANT STOMACH
Author(s) -
OHGA A.,
TANEIKE T.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08465.x
Subject(s) - metiamide , mepyramine , histamine , guanethidine , hexamethonium , medicine , endocrinology , chemistry , contraction (grammar) , muscle contraction , tetrodotoxin , histamine receptor , receptor , atropine , biology , histamine h2 receptor , biochemistry , antagonist , stimulation
1 The effects of histamine on the longitudinal and circular smooth muscle from the rumen and reticulum of the bovine stomach have been analyzed by the use of H 1 ‐ and H 2 ‐receptor antagonists. 2 Histamine caused three different types of response of the smooth muscle preparations: a contraction, contraction followed by relaxation, and a relaxation. These responses were resistant to the effect of tetrodotoxin, atropine, combined treatment with α‐ and β ‐ adrenoceptor blocking agents, hexamethonium and also to guanethidine. 3 Mepyramine antagonized the contractile responses and metiamide antagonized the relaxation responses in a highly selective and competitive manner. 4 It is concluded that histamine‐induced excitatory and inhibitory responses of the smooth muscles from the bovine forestomach are mediated by histamine H 1 ‐ and H 2 ‐receptors, respectively.