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EFFECTS OF END‐TIDAL CONCENTRATIONS OF CYCLOPROPANE, HALOTHANE AND DIETHYL ETHER ON PERIPHERAL AUTONOMIC NEUROEFFECTOR SYSTEMS IN THE RAT
Author(s) -
CLANACHAN A.S.,
MUIR T.C.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08454.x
Subject(s) - halothane , neuroeffector , cyclopropane , chemistry , anesthesia , diethyl ether , inhalation , stimulation , medicine , ring (chemistry) , organic chemistry , chromatography
1 The effects of the inhalation anaesthetics, cyclopropane, halothane and diethyl ether were examined on peripheral neuroeffector systems in the pithed and in the conscious rat. 2 In the absence of a suitable means of accurately quantifying doses of inhalation anaesthetics given to small animals, an apparatus was constructed whereby end‐tidal gas samples were collected semi‐automatically from the mechanically ventilated rat. 3 Cyclopropane (15.3 and 29.3% end‐tidal), halothane (0.20, 0.52 and 0.83% end‐tidal) and diethyl ether (2% and 4% end‐tidal) lowered the arterial pressure of the pithed rat. Heart rate was increased by diethyl ether 4%, decreased by halothane and unchanged by cyclopropane. 4 While each anaesthetic depressed the pressor responses to sympathetic nerve stimulation, cyclopropane increased and halothane and diethyl ether depressed the pressor responses to exogenous noradrenaline. 5 Each anaesthetic reduced the motor responses of the smooth muscle of the colon to parasympathetic stimulation. 6 The significance of the effects on peripheral neuroeffector systems is discussed in relation to the overall circulatory changes produced by these anaesthetics in the whole animal.