Premium
SODIUM‐DEPENDENT CARDIAC GLYCOSIDE BINDING: EXPERIMENTAL EVIDENCE AND HYPOTHESIS
Author(s) -
FRICKE U.,
KLAUS W.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08453.x
Subject(s) - digitoxin , glycoside , cardiac glycoside , digoxin , ouabain , chemistry , sodium , binding site , stereochemistry , guinea pig , biophysics , biochemistry , medicine , endocrinology , biology , organic chemistry , heart failure
1 The influence of increasing Na + concentrations on the binding of digitoxin, digoxin and ouabain was examined in a Na + ‐K + ‐ATPase preparation of guinea‐pig hearts 2 Two distinct processes seem to be involved in this interaction: one binding process was activated at low Na + concentrations. The maximum binding capacities were different and the K 0.5 values were nearly identical for the cardiac glycosides studied. 3 In contrast, the second binding process was activated at appreciably higher Na + concentrations, the maximum binding capacities were almost identical and the K 0.5 values were different for the cardiac glycosides studied. 4 On the basis of these results attempts are made to explain the well known differences in the myocardial accumulation of cardiac glycosides.