Premium
ENHANCEMENT BY OXOTREMORINE OF ACETYLCHOLINE RELEASE FROM THE RAT PHRENIC NERVE
Author(s) -
DAS M.,
GANGULY D.K.,
VEDASIROMONI J.R.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb08445.x
Subject(s) - oxotremorine , acetylcholine , stimulation , phrenic nerve , cholinergic , diaphragm (acoustics) , chemistry , curare , endocrinology , neuromuscular junction , medicine , biology , neuroscience , respiratory system , muscarinic acetylcholine receptor , biochemistry , loudspeaker , physics , receptor , acoustics
1 Oxotremorine (10.5 μM) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation. 2 The paralytic effect of oxotremorine was absent when the diaphragm was stimulated directly in the presence of hemicholinium‐3 (0.42 mM), at a time when twitch responses to indirect stimulation ceased completely. 3 Oxotremorine, at two different pharmacologically active doses, strikingly increased the resting as well as electrically evoked release of acetylcholine into the bathing fluid from the phrenic nerve‐diaphragm preparation. 4 This presynaptic effect of oxotremorine may explain its pharmacological effects at the cholinergic synapses studied so far.