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EFFECTS OF γ‐AMINOBUTYRIC ACID ON NERVE TERMINAL EXCITABILITY IN A SLICE PREPARATION OF CUNEATE NUCLEUS
Author(s) -
HAYES ANN G.,
SIMMONDS M.A.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07804.x
Subject(s) - cuneate nucleus , depolarization , chemistry , neuroscience , bicuculline , afferent , nucleus , gamma aminobutyric acid , biophysics , biology , biochemistry , gabaa receptor , receptor
1 Superfusion of a slice preparation of the rat cuneate nucleus with γ‐aminobutyric acid (GABA) depolarized the afferent nerve fibres and increased their excitability. However, before the depolarization had reached its peak the increased excitability reversed to a decreased excitability, an effect which outlasted the depolarization. 2 Both components of the GABA excitability response were dose‐related, CI “‐dependent and antagonized by bicuculline. 3 Possible mechanisms underlying the sequence of excitability changes are discussed.