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EFFECTS OF DRUGS ON THE ACCUMULATION AND SPONTANEOUS RELEASE OF NORADRENALINE IN THE RAT ANOCOCCYGEUS MUSCLE
Author(s) -
DOGGRELL S.A.,
WOODRUFF G.N.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07798.x
Subject(s) - muscle contraction , pharmacology , norepinephrine , chemistry , medicine , endocrinology , dopamine
1 The ability of drugs to inhibit noradrenaline accumulation and to release noradrenaline was studied in the isolated anococcygeus muscle of the rat. 2 Noradrenaline, tyramine, 2‐amino, 6,7‐dihydroxy‐1,2,3,4‐tetrahydronaphthalene (ADTN), 2‐amino, 6,7‐dimethoxy‐1,2,3,4‐tetrahydronaphthalene (dimethyl ADTN), and 5‐hydroxytryptamine were all potent inhibitors of noradrenaline accumulation and potent releasers of noradrenaline. ADTN was accumulated by the rat isolated anococcygeus muscle. 3 Amphetamine and desipramine were potent inhibitors of noradrenaline accumulation but poor releasers of noradrenaline. 4 Methoxamine, oxymetazoline, acetylcholine, and angiotensin were poor inhibitors of noradrenaline accumulation and did not release noradrenaline. 5 The mechanism of action of these drugs is discussed.