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INTERACTION OF PENTOBARBITONE AND γ‐AMINOBUTYRIC ACID ON MAMMALIAN SYMPATHETIC GANGLION CELLS
Author(s) -
BROWN D.A.,
CONSTANTI A.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07791.x
Subject(s) - aminobutyric acid , sympathetic ganglion , neuroscience , ganglion , sympathetic nervous system , pentobarbital , chemistry , pharmacology , endocrinology , biology , biochemistry , blood pressure , receptor
1 Interactions of bath‐applied pentobarbitone and γ‐aminobutyric acid (GABA) on neurones in isolated superior cervical ganglia of the rat have been examined with intracellular microelectrodes. 2 Pentobarbitone itself (30 μ m ‐1 m m ) showed no clear or consistent GABA‐like effects: changes in resting input conductance and membrane potential were small and variable. 3 Pentobarbitone (100 μ m ) strikingly enhanced the conductance increases produced by GABA and 3‐aminopropanesulphonic acid, and reversed the depression of GABA‐evoked responses by bicucul‐line. 4 It is concluded that reversal of bicuculline action at the membrane conductance level might be explained by augmentation of GABA‐action. This augmentation cannot be attributed to ‘partial agonist’ properties of pentobarbitone or to interference with glial transport processes.