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THE NEURONAL ORIGIN OF PROSTAGLANDIN RELEASED FROM THE RABBIT PORTAL VEIN IN RESPONSE TO ELECTRICAL STIMULATION
Author(s) -
GREENBERG R.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07777.x
Subject(s) - stimulation , portal vein , rabbit (cipher) , prostaglandin , electric stimulation , neuroscience , medicine , chemistry , pharmacology , endocrinology , biology , computer science , computer security
1 Transmural electrical stimulation of the isolated portal vein of the rabbit was accompanied by the release of a prostaglandin‐like substance (PLS). Thin layer chromatography coupled with bioassay indicated that this substance was probably prostaglandin E 2 (PGE 2 ). 2 Indomethacin potentiated the response of the portal vein to electrical stimulation at 2 Hz and abolished the release of the PLS. 3 There was no significant change in the amount of PLS released from the portal vein in response to electrical stimulation at 2 Hz when the contractile response of the portal vein was prevented by pretreatment with phentolamine or guanethidine. 4 In vitro denervation of the portal vein with 6‐hydroxydopamine or the omission of Ca 2+ from the bathing solution caused a significant reduction in the amount of PLS released from the portal vein in response to electrical stimulation at 2 hertz. 5 It is concluded that electrical stimulation of the isolated portal vein of the rabbit is accompanied by the release of a PLS, probably PGE 2 , from a neuronal source. The synthesis and release of the PLS is Ca 2+ ‐dependent.