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EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT
Author(s) -
MIRANDA H.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07755.x
Subject(s) - vas deferens , acetylcholine , medicine , endocrinology , chemistry , stimulation , dopamine , anxiolytic , pharmacology , receptor
1 The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. 2 Oxypertine (4.4 × 10 −10 m to 2.6 × 10 −5 m ) antagonized competitively the effects of noradrenaline (pA 2 = 7.2), 5‐hydroxytryptamine (pA 2 = 8.6) and dopamine (pA 2 = 9.8). 3 Oxypertine (8.8 × 10 −9 m to 2.6 × 10 −5 m ) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. 4 The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. 5 Oxypertine failed to antagonize the responses to potassium chloride. 6 These findings are compared with the effects of other antidepressant drugs.