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TIME COURSES OF THE ANTI‐ANAPHYLACTIC AND ANTI‐INFLAMMATORY EFFECTS OF DEXAMETHASONE IN THE RAT AND MOUSE
Author(s) -
CHURCH M.K.,
MILLER P.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07751.x
Subject(s) - ed50 , dexamethasone , histamine , anaphylaxis , bronchoconstriction , pharmacology , medicine , allergy , anaphylactic reactions , immunology , chemistry , asthma , receptor
1 The time course of the activity of dexamethasone has been studied in a variety of anaphylactic and inflammatory reactions in the rat and the mouse. 2 The times of peak activity of dexamethasone, expressed as time between oral dosage and induction of response, and the approximate ED 50 values (mg/kg) found were: anaphylactic bronchoconstriction in rats, 12–24 h, ED 50 1.8; passive cutaneous anaphylaxis in rats, 6 h, ED 50 0.04; cutaneous reactions to histamine in rats, 4 h, ED 50 0.01; carrageenin‐induced paw oedema in rats, 4 h, ED 50 0.03; pinnal anaphylaxis in mice, 6 h, ED 50 0.82; histamine‐induced pinnal reactions in mice, 6 h, ED 50 0.05. 3 In rats, the characteristics of the inhibitory effects of dexamethasone indicate a differential activity against anaphylactic and inflammatory reactions and between different types of inflammatory reactions. Possible reasons for these differences are discussed. 4 In mice there was little difference between the inhibition by dexamethasone of cutaneous allergic and histamine‐induced reactions. 5 Pinnal anaphylaxis in mice was potentiated by dexamethasone given 1–2 h before challenge.