Premium
COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6‐OXO‐PROSTAGLANDIN F 1α WITH THOSE OF PROSTAGLANDIN E 2 IN RATS AND RABBITS
Author(s) -
ARMSTRONG J.M.,
LATTIMER N.,
MONCADA S.,
VANE J.R.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07014.x
Subject(s) - prostacyclin , prostaglandin e2 , prostaglandin , prostaglandin e , endocrinology , medicine , microgram , iloprost , prostaglandins f , chemistry , biochemistry , in vitro
1 Vasodepressor effects of prostacyclin (5z‐5,6‐didehydro‐9‐deoxy‐6,9a‐epoxyprostaglandin F 1 ) and its decomposition product 6‐oxo‐prostaglandin F 1α (6‐oxo‐PGF 1α ) have been compared with those of prostaglandin E 2 (PGE 2 ) in anaesthetized rats and rabbits. 2 In rats intravenous prostacyclin produced hypotension and was 4–8 times more potent than PGE 2 and about 128 times more potent than 6‐oxo‐PGF 1α . 3 In rabbits also, intravenous prostacyclin (less than 2 μg/kg) produced hypotension and was twice as active as PGE 2 and approximately 250 times more active than 6‐oxo‐PGF 1α . 4 In rats and rabbits vasodepressor responses induced by prostacyclin were similar in magnitude after either intravenous or intra‐aortic administration. 5 Thus, in both species prostacyclin resembles PGE 2 in producing vasodepression but does not lose activity on passage through the lungs. The results emphasize the need to consider prostacyclin in addition to PGE 2 as a major determinant influencing blood pressure.