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THE EFFECTS OF GLYCEROL DETUBULATION, OF MANGANESE IONS, OF DANTROLENE AND OF NITRATE IONS ON THE RESPONSES OF ISOLATED CHRONICALLY DENERVATED SOLEUS MUSCLES OF THE MOUSE TO ACETYLCHOLINE
Author(s) -
HALL MOIRA T.,
MALEQUE M.A.,
WADSWORTH R.M.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07012.x
Subject(s) - acetylcholine , dantrolene sodium , chemistry , dantrolene , contraction (grammar) , biophysics , manganese , muscle contraction , endoplasmic reticulum , depolarization , ion , medicine , endocrinology , calcium , biochemistry , biology , organic chemistry
1 In the isolated chronically denervated soleus muscle of the mouse acetylcholine produced a biphasic contraction. 2 In muscles detubulated by glycerol treatment, the first phase of the acetylcholine contraction was almost abolished, but the second was only slightly reduced or was unaffected. 3 Manganese ions (10 mM) reduced the first phase of the acetylcholine response, but enhanced the second. 4 Dantrolene sodium (5.94 times 10 −5 M) reduced the first phase of the acetylcholine response, but not the second. 5 Nitrate ions (118 mM) augmented the first phase but not the second. 6 It was concluded that the first phase requires the excitation‐contraction‐coupling sequence: membrane depolarization‐T‐tubules‐Ca 2+ release from sarcoplasmic reticulum. In contrast, the second phase appears to occur independently of these processes.