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REVERSAL OF GUANETHIDINE BLOCKADE OF SYMPATHETIC NERVE TERMINALS BY TETRAETHYLAMMONIUM AND 4‐AMINOPYRIDINE
Author(s) -
KIRPEKAR MADHURI,
KIRPEKAR S.M.,
PRAT J.C.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07008.x
Subject(s) - guanethidine , tetraethylammonium , chemistry , stimulation , 4 aminopyridine , inhibitory postsynaptic potential , blockade , sympathetic ganglion , endocrinology , perfusion , medicine , anesthesia , pharmacology , potassium , biochemistry , potassium channel , receptor , organic chemistry
1 The effect of tetraethylammonium (TEA) and 4‐aminopyridine (4‐AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4‐AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4‐AP, the inhibitory effect of guanethidine reappeared 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4‐AP is discussed.