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THE CARDIOVASCULAR EFFECTS OF CYCLOPROPANE IN THE INTACT, DECEREBRATE AND PITHED RABBIT PREPARATIONS
Author(s) -
HUGHES R.L.,
MACKENZIE J.E.
Publication year - 1978
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1978.tb07007.x
Subject(s) - cyclopropane , efferent , medicine , heart rate , baroreceptor , blood pressure , peripheral , reflex , in vivo , chemistry , mean arterial pressure , anesthesia , endocrinology , afferent , biology , ring (chemistry) , microbiology and biotechnology , organic chemistry
1 The anaesthetic cyclopropane was given to intact, decerebrate and pithed unanaesthetized rabbit preparations to determine the relative importance in vivo of its central and peripheral cardiovascular effects. 2 Cyclopropane elevated both the heart rate and the mean arterial pressure in the intact rabbit. 3 In the decerebrate rabbit, cyclopropane elevated the heart rate and efferent cervical preganglionic nerve activity and diminished the magnitude of these components of the aortic baroreceptor reflex, the mean arterial pressure being unaffected. 4 Apart from slight myocardial depression, cyclopropane was largely without effect in the pithed rabbit. 5 It is concluded that cyclopropane produces its cardiovascular effects by supra‐collicular activation eliciting an elevation of mean arterial pressure, a central sub‐collicular activation producing an increase in heart rate, and that in vivo the peripheral effects of cyclopropane are of minimal importance in comparison to these central effects.