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THE NATURE OF POTASSIUM CHLORIDE‐INDUCED RELAXATIONS OF THE RAT ANOCOCCYGEUS MUSCLE
Author(s) -
GIBSON A.,
JAMES T.A.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb16758.x
Subject(s) - ouabain , chemistry , procaine , inhibitory postsynaptic potential , tetrodotoxin , potassium , stimulation , chloride , biophysics , sodium , muscle contraction , medicine , endocrinology , anatomy , pharmacology , biology , organic chemistry
1 The nature of KCl‐induced relaxations of the rat anococcygeus muscle was investigated. 2 The relaxations were mimicked by other K + salts, but not by NaCl. 3 The muscle was more susceptible to the relaxant effects of KCl than the contractile effects. 4 Addition of ouabain (100 μ m ) had no effect on the relaxations. 5 The relaxations were abolished by tetrodotoxin (5 μg/ml), procaine (500 μ m ), and by section of the inhibitory nerves. 6 The results suggest that KCl‐induced relaxations are due to stimulation of the inhibitory nerves by K + .