Premium
PRENYLAMINE‐INDUCED CONTRACTURE OF FROG SKELETAL MUSCLE
Author(s) -
KIRSTEN E.B.,
LUSTIG KAREN C.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb16753.x
Subject(s) - contracture , chemistry , tonic (physiology) , muscle contraction , skeletal muscle , sartorius muscle , medicine , endocrinology , anatomy , biology , genetics
1 Experiments were performed to determine the influence of prenylamine on excitation‐contraction coupling in frog sartorius muscle. 2 Prenylamine (0.2‐1.0 mM) produced a biphasic contracture in skeletal muscle characterized by an initial phasic and subsequent tonic contracture. 3 Neither dantrolene nor procaine blocked the prenylamine‐induced contracture. Pretreatment with 100 m M K + blocked the phasic but not the tonic component of the prenylamine contracture. 4 Prenylamine produced a sustained increase in 45 Ca efflux at all concentrations that produce contracture. These concentrations of prenylamine also depressed the action potential, muscle twitch and resting potential. 5 Low concentrations of prenylamine (0.05 mM) which produced neither contracture, 45 Ca efflux nor 45 Ca influx, depressed the action potential, muscle twitch and K + contracture. 6 The results suggest that prenylamine not only alters calcium mobility but also membrane permeability to other ions.