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CENTRAL MECHANISM OF VASOPRESSIN‐INDUCED CHANGES IN ANTIDIURETIC HORMONE RELEASE
Author(s) -
BHARGAVA K.P.,
KULSHRESTHA V.K.,
SRIVASTAVA Y.P.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb16750.x
Subject(s) - vasopressin , endocrinology , medicine , antidiuretic , vasopressin antagonists , diuretic , chemistry , tachyphylaxis , antagonist , receptor
1 Intracerebroventricularly (i.c.v.) administered vasopressin (0.001–1.0 u) in dogs anaesthetized with chloralose produced a dose‐dependent increase in urine flow with a concomitant decrease in the levels of antidiuretic hormone (ADH) in jugular vein blood. 2 Higher doses of vasopressin (1.5–2.0 u, i.c.v.) on the other hand had an antidiuretic effect and produced an increase in blood ADH level. 3 Pretreatment (i.c.v.) with a β‐adrenoceptor antagonist completely blocked the diuretic response of low doses of vasopressin (i.c.v.) but did not influence the antidiuretic response obtained with high doses. 4 Repeated administration of vasopressin (1.0 u, i.c.v.) induced tachyphylaxis; central catecholamine depletion with tetrabenazine significantly inhibited the vasopressin‐induced diuretic response. 5 It is concluded that intracerebroventricular vasopressin‐induced changes in ADH secretion are mediated through the release of catecholamines in the central nervous system.