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INTRARENAL STIMULATION OF RENIN SECRETION BY FRUSEMIDE IN THE ISOLATED KIDNEY OF THE RAT
Author(s) -
VANDONGEN R.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb16749.x
Subject(s) - macula densa , renin–angiotensin system , endocrinology , medicine , kidney , furosemide , perfusion , stimulation , chemistry , angiotensin ii , diuresis , secretion , plasma renin activity , urine flow rate , receptor , biology , blood pressure
1 Intrarenal infusion of frusemide markedly stimulated renin secretion in the isolated perfused kidney of the rat. 2 Renin values increased from 24 ± 6 to 195 ± 34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) × flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 ±2 ( P >0.05) and 47 ±18 ( P < 0.001). This stimulatory effect was also observed when urine flow was interrupted by ligation of the ureters. 3 The changes in renal perfusion pressure and perfusate flow rate were not significantly different from the control values. 4 These findings indicate the existence of an intrarenal site of action for frusemide on renin secretion. 5 Since frusemide did not appear to alter perfusion pressure or flow rate, and was effective when urine flow was abolished, a dominant role for a vascular or macula densa receptor mechanism seems unlikely. A direct effect of frusemide on the renin secreting cell is therefore suggested.