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SOME EFFECTS OF INTRAVENOUS PROSTAGLANDIN E 1 AND ENDOTOXIN IN YOUNG CHICKENS
Author(s) -
ARTUNKAL AKGÜL A.,
MARLEY E.,
STEPHENSON J. D.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb09736.x
Subject(s) - prostaglandin , hyperthermia , thermoregulation , shigella dysenteriae , prostaglandin e2 , anesthesia , endocrinology , medicine , chemistry , biochemistry , escherichia coli , gene
1 The effects of intravenous prostaglandin E 1 and endotoxin were studied in young chickens (11–17 days old). 2 At a thermoneutral ambient temperature (31°C), intravenous prostaglandin E 1 produced behavioural and electrocortical sleep, increased oxygen consumption and, after an initial fall, elevated body temperature. Below thermoneutrality (16°C), the initial hypothermic effect was more marked and oxygen consumption was lowered. 3 The soporific actions of prostaglandin E 1 were sufficient to counteract dexamphetamine‐induced behavioural and electrocortical arousal and vocalization. 4 Intravenous injection of the O‐somatic antigen of Shigella dysenteriae evoked, after a latent period, long lasting hyperthermia. This indicates that in young chicks the blood brain barrier is probably permeable to endotoxins.