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REDUCED ADRENAL AMINE SYNTHESIS IN SPONTANEOUSLY HYPERTENSIVE RATS AFTER LONG‐TERM TREATMENT WITH PROPRANOLOL
Author(s) -
ÅBLAD B.,
ALMGREN O.,
CARLSSON A.,
HENNING M.,
JONASSON J.,
UUNG B.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08422.x
Subject(s) - propranolol , medicine , endocrinology , blood pressure , norepinephrine , dopamine
Male spontaneously hypertensive rats were either fed a diet containing 3 mg/g of (±)‐propranolol, giving a mean daily intake of 178 ± 4.2 mg/kg, or a control diet from 7 weeks of age for 6 months. Three days after cessation of propranolol‐treatment, the arterial blood pressure of the treated group was about 10% lower than that of the control group. Adrenal dopamine content and tyrosine hydroxylase activity were reduced to 76% and 71% of the control values, respectively. The results indicate that propranolol causes a reduced sympathetic discharge through its central action, although blockade of β‐adrenoceptor‐mediated local regulatory mechanisms cannot be excluded.