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THE ANTIDYSRHYTHMIC AMINOSTEROID, ORG 6001, REDUCES THE ST‐SEGMENT ELEVATION PRODUCED BY CORONARY OCCLUSION IN THE DOG
Author(s) -
MARSHALL R.J.,
PARRATT J.R.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08421.x
Subject(s) - occlusion , coronary occlusion , st segment , medicine , cardiology , coronary artery occlusion , anesthesia , st elevation , electrocardiography , myocardial infarction
ST‐segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open‐chest anaesthetized dogs. This was greatly reduced by the prior administration of the antidysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K + egress from ischaemic cells.