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THE EFFECT OF ATROPINE ON ACID SECRETION STIMULATED BY ACETYLCHOLINE, HISTAMINE AND GASTRIN IN THE ISOLATED WHOLE STOMACH OF THE RAT
Author(s) -
BUNCE K.T.,
MARSH GILLIAN F.,
PARSONS M.E.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08416.x
Subject(s) - atropine , histamine , acetylcholine , gastric acid , medicine , endocrinology , cholinergic , gastrin , secretion , chemistry , biology
1 An isolated stomach preparation from immature rats has been used to study the effect of atropine on gastric acid secretion. 2 The acid secretory response to acetylcholine was not inhibited by atropine at a concentration of 0.3 μM. Concentrations of atropine of 1 to 3 μM produced a measurable inhibition of acid secretion, and a concentration of atropine of 10 μM caused a complete block of acid secretion which could not be surmounted by high concentrations of acetylcholine. 3 The acid secretory response to histamine was not inhibited by concentrations of atropine of up to 1 mM. 4 Concentrations of atropine of 1 μM and 10 μM did not inhibit gastrin‐stimulated acid secretion, although a significant inhibition of acid output was observed with atropine at concentrations of 0.1 mM and 1 mM. 5 These findings are discussed in relation to the role of cholinergic mechanisms in the control of gastric acid secretion.