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RELAXATION OF ISOLATED AORTA OF THE RABBIT BY PICOLINIC ACIDS
Author(s) -
ASANO M.,
HIDAKA H.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08414.x
Subject(s) - propranolol , aorta , chemistry , atropine , alkyl , residue (chemistry) , stimulation , medicine , endocrinology , biochemistry , biology , organic chemistry
1 When the isolated thoracic aorta of the rabbit was contracted with prostaglandin F 2α , 5‐alkylpicolinic acids produced dose‐dependent relaxations. 2 Picolinic acid, 2,5‐pyridinedicarboxylic acid and 5‐acetylpicolinic acid which do not have the 5‐alkyl residue failed to relax blood vessels. 3 The vascular relaxation was dependent on the number of carbon atoms in the 5‐alkyl compounds. 4 Relaxations which occurred with 5‐alkylpicolinic acids were not affected by pretreatment with either propranolol or atropine. 5 It is concluded that the 5‐alkyl residue is necessary for the vascular relaxation with 5‐alkylpicolinic acid and that it was not produced by stimulation of β‐adrenoceptors or cholinoceptors but rather through an activation of the basic process.