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THE EFFECTS OF SODIUM CROMOGLYCATE ON HISTAMINE AEROSOL‐INDUCED REFLEX BRONCHOCONSTRICTION IN THE ANAESTHETIZED DOG
Author(s) -
JACKSON D.M.,
RICHARDS I.M.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08413.x
Subject(s) - bronchoconstriction , histamine , reflex , propranolol , anesthesia , cromolyn sodium , chemistry , stimulation , medicine , pharmacology , endocrinology , asthma , airway
1 The effects have been studied of sodium cromoglycate (SCG), given by aerosol or intravenously, on reflex bronchoconstriction induced by histamine aerosol in the anaesthetized dog. 2 Four breaths of an aerosol generated from a 2% solution of SCG significantly inhibited the vagally mediated increase in total lung resistance (R L ) produced by histamine. 3 SCG given intravenously as bolus injections (5–500 μg/kg) produced a dose‐dependent reversal of a sustained reflex bronchoconstriction induced by histamine aerosol. Propranolol (500 μg/kg) did not prevent this reversal. 4 SCG did not inhibit the increase in R L produced by supramaximal electrical stimulation of a vagus nerve. 5 The possibility is discussed that SCG may reduce the activity of lung irritant receptors in the anaesthetized dog.