Premium
CENTRAL AND PERIPHERAL NORADRENALINE IN THE TWO KIDNEY MODEL OF RENOVASCULAR HYPERTENSION IN THE RAT
Author(s) -
DARGIE H.J.,
FRANKLIN S.S.,
REID J.L.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb08406.x
Subject(s) - renovascular hypertension , constriction , peripheral , medicine , kidney , endocrinology , pathophysiology of hypertension , norepinephrine , blood pressure , dopamine
1 Plasma noradrenaline concentrations were similar in rats following unilateral renal arterial constriction (two kidney Goldblatt model) and in sham‐operated control rats. 2 The development of hypertension was not affected by pretreatment with intracisternal injections of 6‐hydroxydopamine. 3 These data suggest that sympathetic mechanisms do not contribute to the development of hypertension in this model.