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CATECHOL‐SUBSTITUTED PHENOXY‐PROPANOLAMINES: ADRENOCEPTOR ACTIVITY IN THE ANAESTHETIZED CAT
Author(s) -
DOWD H.,
KEH G.S.,
RAPER C.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07741.x
Subject(s) - chronotropic , isoprenaline , chemistry , catechol , norepinephrine , medicine , hindlimb , endocrinology , pharmacology , perfusion , epinephrine , blood pressure , dopamine , heart rate , biochemistry , stimulation
1 The pharmacological actions of racemic noradrenaline, adrenaline, isoprenaline and N‐t ‐butylnoradrenaline have been compared with those of their corresponding derivatives containing an oxymethylene (OXY) link between the ring and ethanolamine side chain. 2 The compounds were tested in the anaesthetized cat for their ability to produce positive chronotropic effects, bronchodilator actions, changes in perfusion pressure in the perfused hind limb and decreases in soleus muscle contractions. 3 In comparison with the parent compounds, the OXY‐derivatives of adrenaline and noradrenaline had very weak α‐adrenoceptor stimulant effects.