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THE EFFECT OF SULPHAMETHOXYPYRIDAZINE ON LIVER AND PLASMA LEVELS OF VITAMIN A IN RATS
Author(s) -
BRAVO MARÍA E.,
MONCKEBERG F.,
URBINA J.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07739.x
Subject(s) - vitamin , medicine , endocrinology , chemistry , blood proteins , intraperitoneal injection , secretion , plasma levels , plasma concentration , biology
1 Long‐acting sulphonamides are highly bound to plasma proteins; the present study deals with the effects of this binding property upon a vitamin A compound also transported by plasma proteins. 2 Sulphamethoxypyridazine was administered in rats either orally or by intraperitoneal injection. 3 A significant fall in plasma vitamin A level and an increase in hepatic vitamin A concentration were observed. 4 These results suggest an interference by sulphamethoxypyridazine with the transport of vitamin A, either through competition between the drug and vitamin A for binding sites of plasma proteins, or through altered secretion of the vitamin from the liver.