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ASPIRIN AT THERAPEUTIC CONCENTRATIONS DOES NOT AFFECT 5‐HYDROXYTRYPTAMINE UPTAKE BY PLATELETS
Author(s) -
DRUMMOND A.H.,
MacINTYRE D.E.,
OLVERMAN H.J.,
GORDON J.L.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07735.x
Subject(s) - platelet , aspirin , arachidonic acid , pharmacology , chemistry , serotonin , prostaglandin , biochemistry , medicine , receptor , enzyme
Aspirin at therapeutic concentrations does not inhibit the uptake of 5‐hydroxytryptamine (5‐HT) by blood platelets nor induce release of 5‐HT from platelets, although platelet aggregation responses to collagen and arachidonic acid (which are dependent on platelet prostaglandin synthesis) are abolished. This does not support an earlier claim that aspirin's effects on platelet function include inhibition of 5‐HT transport.