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RENAL BLOOD FLOW AUTOREGULATION AND RENAL VENOUS PROSTAGLANDINS IN THE PUMP‐PERFUSED CANINE KIDNEY ( In situ )
Author(s) -
DIGHE K.K.,
HALL JANET C.,
SMITH G.W.,
UNGAR A.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07723.x
Subject(s) - autoregulation , renal blood flow , kidney , medicine , endocrinology , perfusion , radioimmunoassay , prostaglandin , renal circulation , chemistry , venous blood , blood pressure
1 Renal autoregulation of blood flow was re‐examined in the pump‐perfused canine kidney and concentrations of prostaglandins E and F in the renal venous plasma were measured by radioimmunoassay. 2 At low perfusion pressures, below the range of autoregulation, prostaglandin E and F concentrations rose and calculated prostaglandin E secretion rate fell. 3 Meclofenamate (10 mg/kg, i.v.) reduced renal blood flow and prostaglandin E and F secretion rates, but did not abolish autoregulation. 4 Renal prostaglandins do not appear to mediate autoregulation in the kidney but may affect the level at which flow is controlled.