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EFFECT OF APOMORPHINE AND ITS N ‐PROPYL HOMOLOGUE ON ETHANOL WITHDRAWAL HEAD TWITCHES IN MICE
Author(s) -
PEARL J.,
WOODWARD W.A.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07565.x
Subject(s) - apomorphine , ethanol , chemistry , pharmacology , anesthesia , medicine , biochemistry , receptor , agonist
Collier, Hammond & Schneider (1976) reported that apomorphine, given orally, decreased the incidence of head twitches induced by ethanol withdrawal. These results were confirmed in the present study. Moreover, the N ‐propyl homologue of apomorphine was about 45 times more potent than apomorphine in affecting head twitching. Discussion Apomorphine inhibited head twitching in mice after ethanol withdrawal in accordance with the results of Collier et al. (1976). That the N ‐propyl compound was considerably more potent than apomorphine in preventing head twitching agrees with the majority of results of previous studies in which different tests were used (Ashton et al. , 1976; Pearl, 1977).