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COMPARATIVE POTENCIES OF AMPHETAMINE, FENFLURAMINE AND RELATED COMPOUNDS IN TASTE AVERSION EXPERIMENTS IN RATS
Author(s) -
BOOTH D.A.,
PILCHER C.W.T.,
D'MELLO G.D.,
STOLERMAN I.P.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07560.x
Subject(s) - fenfluramine , amphetamine , potency , taste aversion , taste , pharmacology , methamphetamine , neurochemical , dextroamphetamine , stimulation , chemistry , psychology , medicine , neuroscience , biochemistry , dopamine , serotonin , receptor , in vitro
1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion). 2 There was very little difference between the potencies of (+)‐ and (‐)‐amphetamine. 3 p ‐Chloromethamphetamine was a more potent aversive agent than methamphetamine. 4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine > p ‐hydroxyamphetamine. 5 Cocaine induced only moderate taste aversions, even at high doses. 6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.