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THE CONTRIBUTION OF PROSTAGLANDINS IN THE MUSCLE OF HUMAN ISOLATED SMALL INTESTINE TO NEUROGENIC RESPONSES
Author(s) -
BENNETT A.,
STOCKLEY HELEN L.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07550.x
Subject(s) - contractility , circular muscle , contraction (grammar) , medicine , endocrinology , muscle contraction , stimulation , muscle tone , prostaglandin , cholinergic , acetylcholine , prostaglandin e , biology , anatomy , chemistry , smooth muscle , neuroscience
1 In strips cut parallel to the longitudinal or circular muscle, indomethacin (2‐10 μg/ml) usually lowered the tone, thus probably accounting for the reduction of nerve‐mediated relaxations to electrical field stimulation. 2 In longitudinal muscle strips, indomethacin enhanced contractions which occurred during electrical stimulation, probably because tone fell, but antagonized after‐contractions. By contrast, in the circular muscle indomethacin reduced initial contractions but enhanced after‐contractions. 3 Prostaglandin E 2 counteracted all of the effects of indomethacin in the longitudinal muscle and most of those in the circular muscle; prostaglandin F 2α restored circular muscle tone. 4 The results suggest that prostaglandins affect the muscle directly and contribute to the regulation of tone. They may also mediate non‐cholinergic contraction in longitudinal muscle and suppress contractility in the circular muscle.