Premium
RELAXATION OF SMOOTH MUSCLE FOLLOWING CONTRACTION ELICITED BY SYMPATHETIC NERVE STIMULATION in vivo
Author(s) -
ECCLES R.,
MacLEAN A.G.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07547.x
Subject(s) - nictitating membrane , contraction (grammar) , phenoxybenzamine , in vivo , stimulation , neuroeffector , chemistry , medicine , endocrinology , anesthesia , biology , mathematics , receptor , statistics , classical conditioning , microbiology and biotechnology , conditioning
1 A method for studying in vivo the process of neuroeffector transmission in the nictitating membrane and nasal blood vessels of the cat is described. 2 Administration of desmethylimipramine or cocaine caused increases in both the amplitude and duration of the nasal and membrane responses which may be explained by inhibition of neuronal uptake of noradrenaline. 3 Phenoxybenzamine depressed the responses to nerve stimulation, but had little effect on the relationship between response amplitude and rate of recovery. 4 The relationship between response amplitude and rate of recovery is discussed and related to the sigmoid shape of a log concentration‐response curve.