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THE EFFECT OF DIURETICS ON THE FAECAL EXCRETION OF WATER AND ELECTROLYTES IN HORSES
Author(s) -
ALEXANDER F.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07539.x
Subject(s) - furosemide , sodium , excretion , potassium , chemistry , feces , diuresis , urine , medicine , endocrinology , zoology , kidney , biology , paleontology , organic chemistry
1 The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2 The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3 Faecal sodium excretion was increased substantially after the administration of frusemide. 4 Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5 Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6 Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr 2 O 3 ) markers.