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LIGATED RENAL PEDICLES AND DURATION OF ACTION OF NEOSTIGMINE AND PYRIDOSTIGMINE
Author(s) -
MILLER R.D.,
RODERICK LAURA
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07534.x
Subject(s) - neostigmine , pyridostigmine , antagonism , ligation , anesthesia , medicine , neuromuscular blockade , duration (music) , cholinesterase , myasthenia gravis , art , receptor , literature
1 The duration of neostigmine or pyridostigmine antagonism of a (+)‐tubocurarine (Tc) neuromuscular blockade was determined in the cat anterior tibialis‐peroneal nerve preparation with and without ligated renal pedicles. 2 The infusion rate of Tc required to maintain a 90% depression of twitch tension was reduced from 8.8 ± 1.4 (s.e.) to 3.4 ± 0.6 μg kg −1 min −1 by renal pedicle ligation. 3 Renal pedicle ligation resulted in an increased duration of antagonism of Tc by both neostigmine and pyridostigmine.